رابطه سطح سرمی ویتامین D3 با شاخص های سندرم متابولیک در بیماران دیابتی و غیر دیابتی

امیر ضیایی; سیما هاشمی پور; تکتم کریم زاده; آزاده جلال پور; امیر جوادی

رابطه سطح سرمی ویتامین D3 با شاخص های سندرم متابولیک در بیماران دیابتی و غیر دیابتی

امیر ضیایی, سیما هاشمی پور, تکتم کریم زاده, آزاده جلال پور, امیر جوادی

چکیده

زمینه وهدف: امروزه مشخص شده است که کمبود ویتامین D عملکرد متابولیک بسیاری از سلول ها از قبیل بخش درون ریز پانکراس را تغییر می دهد. شواهد بالینی و تجربی، پیشنهاد کننده این موضوع هستند که غلظت سرمی ویتامین D فعال به طور معکوس با دیابت نوع دو، اجزای سندرم متابولیک و بیماری های قلبی- عروقی همراهی دارد. این مطالعه به منظور مقایسه سطح سرمی D3 در بیماران مبتلا به دیابت با افراد غیر دیابتی و رابطه آن با شاخص های سندرم متابولیک انجام شد.
روش کار: این مطالعه توصیفی تحلیلی بر روی 69 نفر از مراجعه کنندگان به درمانگاه غدد انجام شد. این افراد در سه گروه شامل افراد دیابتی با کنترل خوب قند خون، افراد دیابتی با کنترل ضعیف و گروه غیر دیابتی بررسی شدند. برای تمام افراد، وزن، قد، فشار خون سیستولیک و دیاستولیک، قند خون ناشتا، قند دو ساعت پس از صرف غذا، درصد هموگلوبین گلیکوزیله، سطح سرمی ویتامین D فعال و لیپیدهای سرم اندازه گیری و ثبت شدند. داده ها با استفاده از آزمون های آماری مجذور کای، تی، آنالیز واریانس، همبستگی پیرسون و آزمون تکمیلی توکی تحلیل شدند.
یافته ها: میانگین سطح سرمی ویتامین D فعال در افراد دیابتی 6/16±5/36 و در افراد غیر دیابتی 1/19±6/56 نانو مول بر لیتر بود (001/0>p). ولی، سطح این ویتامین بین دو گروه با کنترل خوب و ضعیف قند خون و همچنین بین افراد مبتلا به سندرم متابولیک با افراد غیر مبتلا به سندرم متابولیک تفاوت معنی داری نداشت. بین متوسط سطح سرمی ویتامین D3 به تفکیک گروههای مورد مطالعه و وضعیت هر یک از شاخص های سندرم متابولیک اختلاف معنی داری وجود نداشت.
نتیجه گیری: بر اساس یافته ها، سطح سرمی ویتامین D در افراد دیابتی کمتر از افراد سالم بود. در بین بیماران دیابتی بین سطح سرمی ویتامین D3 با طول مدت ابتلا به دیابت، HBA1C ارتباط معنی داری وجود نداشت. همچنین اختلاف معنی داری بین متوسط سطح سرمی مبتلایان و غیر مبتلایان به سندرم متابولیک وجود نداشت. با توجه به نقش این ویتامین در ترشح و اثر انسولین، به نظر می رسد پایش سطح سرمی ویتامین D در بیماران دیابتی و در صورت لزوم تجویز مکمل های آن مفید باشد.

موضوع

ویتامین D ؛ دیابت؛ سندرم متابولیک

تمام متن: PDF XML XML (English) PDF

ارجاعات

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4.25 kB /usr/local/ojs/lib/pkp/lib/htmlpurifier/library/HTMLPurifier/VarParser/Flexible.php

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2.00 kB /usr/local/ojs/cache/t_compile/%%DF^DFD^DFDA949A%%readerReferrals.tpl.php

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5.89 kB /usr/local/ojs/cache/t_compile/%%CC^CCB^CCBBF62B%%footer.tpl.php

`0` Logs	`0` Errors
`1` Memory	`1` Speed

memory	432.94 kB string: PKPApplication::construct
speed	0.311 ms PKPApplication::construct

رابطه سطح سرمی ویتامین D3 با شاخص های سندرم متابولیک در بیماران دیابتی و غیر دیابتی

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